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COL3A1 expression

Expression of COL3A1 mRNA encoding key fibrotic extracellular matrix molecules was down-regulated by pre-miRNA-29b. The results point to the fact that the injury and/or mandible fracture increase the collagen type III metabolism and its dynamics depends on the type of the used bone fixation COL3A1 (EDS4A) Tissue specificityi. The RNA specificity category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA, GTEX and FANTOM5. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected. Read more Tissue proteome. GENERAL INFORMATIONi. General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project. Gene namei. Official gene symbol, which is typically a short form of the gene name, according to HGNC. COL3A1

COL3A1 collagen type III alpha 1 chain [ (human)

Expression of COL3A1 (EDS4A) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers. We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information Survival analysis revealed that BCa patients with higher expression of COL3A1 had a significantly shorter overall survival time and disease free survival time.In conclusion, based on the co-expression analysis, COL3A1 was identified in the association with progression and prognosis of BCa, which might refer a poor prognosisprobably by. The expression vector-mediated RNAi established a HSF cell line with persistent gene knockdown for over 30 days (to 25.21% and 22.12%, respectively). Conclusion: COL1A1 and COL3A1 gene expressions can be specifically and efficiently inhibited in HSFs by either liposome- or vector-mediated SEC transfection The effect of UVA irradiation on the expression of miRNAs as well as circCOL3A1-859267-mediated type I collagen expression was further investigated in HDFs. miR-29a, miR-29b, miR-29c, miR-767, and miR-133a were predicted to bind both circCOL3A1-859267 and COL1A1/COL1A2, however, only miR-29c was shown to bind to circCOL3A1-859267 based on the dual luciferase reporter assay

On the whole, the expression level of Col3a1 mRNA in muscle of LW was higher than that of LL (P < 0.05). Correlation analysis showed that the expression of Col3a1 mRNA in muscle was positively correlated with total and insoluble IMC, but was negatively correlated with IMC solubility for LW pigs (P < 0.01) and LL pigs (P < 0.05), respectively Type III Collagen is a homotrimer, or a protein composed of three identical peptide chains (), each called an alpha 1 chain of type III collagen.Formally, the monomers are called collagen type III, alpha-1 chain and in humans are encoded by the COL3A1 gene.Type III collagen is one of the fibrillar collagens whose proteins have a long, inflexible, triple-helical domain

COL3A1 protein expression summary - The Human Protein Atla

Patients were divided based on level of expression into one of the two groups low (under cut off) or high (over cut off). X-axis shows time for survival (years) and y-axis shows the probability of survival, where 1.0 corresponds to 100 percent. Read more. COL3A1 is not prognostic in colorectal cancer Expression scores of expression calls use the minimum and maximum Rank of the species to normalize the expression to a value between 0 and 100. Low score means that the gene is lowly expressed in the condition Expression : Phenotypes: Gene Literature (3) GO Terms (6) Nucleotides (487) Proteins (42) Interactants (235) Wiki: XB-GENEPAGE-5864291. Gene Symbol: col3a1 Gene Name: collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant) Anatomy terms

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Kaplan-Meier survival analysis revealed that COL3A1 expression was associated with shorter overall survival in the four major histotypes of epithelial ovarian carcinoma patients (P value = 0.026, HR = 2.99 (95% CI 1.089-8.19)). Furthermore, GPR158 and PITHD1 were shown to be histotype-specific prognostic biomarkers, with elevated GPR158. Gene with a very high level of expression: COL3A1. Expression of collagen (COL) proteins from groups 2 and 3 were also confirmed using immunocytochemistry. Western blot analysis showed very high expression levels of COL3A1 protein, and immunocytochemistry analysis showed the presence of extracellular COL3A1 in the W1TR cell line Overexpression of lnc-GULP1-2:1 in KGN cells promoted the expression of COL3A1 and its translocation into the nucleus. Consistently, silencing COL3A1 in KGN cells also significantly inhibited cell proliferation View mouse Col3a1 Chr1:45350698-45388866 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression The influence of COL3A1 on DMFS of TNBC patients analyzed by KM-plotter is shown in Figure 6B, the DMFS of TNBC patients with high-expression COL3A1 was shorter than in those with a low expression thereof. There was no significant difference in the expression level of COL3A1 and DMFS in the overall patients

Lnc-GULP1-2:1 affects the proliferation of granulosa cells by regulating the expression and localization of COL3A1 protein, and may participate in the regulation of ovarian follicle development. This study will provide new insight into molecular mechanisms underlying ovarian follicular development, COL3A1 overexpression promotes metastasis of triple-negative breast cancer and is linked to a poor prognosis in human bladder cancer. COL5A1 contributes to the metastasis of lung adenocarcinoma and clear cell renal cell carcinoma and can suppress the progression of breast invasive ductal carcinoma Col3a1 collagen type III alpha 1 chain [ (Norway rat)] the activation of Pin1 promoted cardiac extracellular matrix deposition and oxidative stress damage by regulating the phosphorylation of the MEK1/2ERK1/2 signaling pathway and the expression of alphaSMA. the diagnostic value of urinary collagen degradation products in a proteinuria-driven. The expression of fibrosis and scar markers, Col3a1 and αSMA, as well as EGFP expression, was significantly reduced after EV treatments, as compared to wound controls (Fig. 4D). Lastly, we did not observe any gender effect on the treatment outcome

COL3A1 gene expression. In view of this, this study ex-plored the expression level of lnc-GULP1-2:1 in granu-losa cells of patients with different ovarian functions and its influence on granulosa cell proliferation and cell cycle regulation, and further investigated the role of lnc-GULP1-2:1 in the modulation of COL3A1 expression The expression of ACTA2, COL3A1, IFN-γ, MMP2, MMP9, TGF-β1, and TNF-α genes was determined by qRT-PCR in healthy and fibrotic liver tissue of the CE patients. TGF-β1 expression was evaluated by immunohistochemistry, and histology was conducted to assess the development of liver fibrosis

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Tissue expression of COL3A1 - Summary - The Human Protein

Expression of COL3A1 in cancer - Summary - The Human

(A) COL3A1 expression was correlated with the disease progression of BCa (GSE13507). (B) and (C) Oncomine database indicated that COL3A1 was up-regulated in BCa, compared with normal bladder, as. CAT#: HP200076. The primer mix has been tested to generate satisfactory qPCR data on ABI 7900HT by using the following PCR program: Stage 1: Activation: 50 °C for 2 min; Stage 2: pre-soak:95 °C for 10 min; Stage 3: Denaturation: 95 °C for 15 sec, Annealing: 60°C for 1 min; Stage 4: Melting curve: 95°C for 15 sec, 60°C for 15 sec, 95°C. The COL3A1 gene encodes for the chains of type III procollagen. Collagen type III have been found in the lamina cribrosa and in the TM [102, 103]. A study that explored the expression of genes using expression profiles data from TM tissue, found a different expression of COL3A1 gene in patients with POAG compared to controls

Type III collagen is a fibrillar-forming collagen comprising 3 alpha-1 (III) chains and is expressed in early embryos and throughout embryogenesis. In adult, type III collagen is a major component of the extracellular matrix in a variety of internal organs and skin (Liu et al., 1997). Cloning and Expression A Relative expression of COL3A1 in glioma (LGG and GBM) and normal brain tissue. After COL3A1 siRNA transfected, SHG44 and A172 ( B ) cells showed reduced COL3A1 levels measured by qRT-PCR. C Wound healing assays indicated that the migratory ability of glioma cells was reduced after transfection COL3A1 (Collagen Type III Alpha 1 Chain) is a Protein Coding gene. Diseases associated with COL3A1 include Ehlers-Danlos Syndrome, Vascular Type and Polymicrogyria With Or Without Vascular-Type Ehlers-Danlos Syndrome.Among its related pathways are Endothelins and Collagen chain trimerization.Gene Ontology (GO) annotations related to this gene include integrin binding and SMAD binding The COL3A1 gene provides instructions for making type III collagen. Collagens are a family of proteins that strengthen and support many tissues in the body. Type III collagen is found in the skin, lungs, intestinal walls, and the walls of blood vessels. The components of type III collagen, called pro-α1 (III) chains, are produced from the.

The expression of COL1A1 and COL3A1 was upregulated in cardiac fibroblasts transfected with adenovirus containing circHIPK3, while their expression was downregulated when fibroblasts were co-transfected with circHIPK3 and miR-29b-3p mimic (Fig. 7e) Collagen III (COL3A1) (NM_000090) Human Over-expression Lysate. CAT#: LY400026 Reviews Write a review. Transient overexpression lysate of collagen, type III, alpha 1 (COL3A1) Datasheet. SDS View other COL3A1 proteins (3) BOGO250! Buy one, get 50% off the 2nd overexpression lysate. USD 550.00. Availability* 5 Days. Size. 100 ug; Size. Request. Expression of Col1 and Col3 were determined via reverse transcription-quantitative polymerase chain reaction with target genes of Collagen Type I Alpha 1 Chain (COL1A1) and Collagen Type III Alpha 1 Chain (COL3A1) Alterations in collagen type I α1 (COL1A1) and collagen type I α 2 (COL1A2) expressionlevels have been reported to predict prognosis in various types of cancer. However, the effect of these biomarkers on hypopharyngeal squamous cell carcinoma (HPSCC) is yet to be fully elucidated. The present study aimed to explore the prognostic significance of COL1A1 and COL1A2 expression levels in HPSCC

A novel mutation in COL3A1 associates to vascular Ehlers-Danlos syndrome with predominant musculoskeletal involvement. Federica Ruscitti, Lucia Trevisan, Giulia Rosti, Fabio Gotta, Our findings provide insight into genetic variants and clinical expression of vEDS, broadening the clinical scenario of the syndrome.,. Col3a1 expression was prominent in the vascular wall, lung mesenchyme, peritoneal lining and the wall of visceral organs. Col3a1was co-expressed with Col1a1 in skin, but not in bone. None of the sense probes for any of the collagen or ADAMTS genes gave a signal above background levels Finally, we found that COL3A1 mRNA expression was upregulated in skin fibroblasts from patients 1 and 2 with the N-terminal bi-allelic mutation. Although this effect was not visible at the protein level and no differences in protein patterns could be detected after western blot analysis, the involvement of another pathway should be considered

Overexpression of COL3A1 confers a poor prognosis in human

  1. The expression of the A085R protein was induced with 0.01, 0.1, and 0.5 mM IPTG for 6 h, and the expression of COL3A1 was induced by heat-shock treatment at 42 or 50 °C, simultaneously. After induction, the bacteria were collected, and total RNA was extracted from these strains and detected by RT-qPCR following the methods described above
  2. It can be studied in the future whether ac4C could influence on COL3A1 mRNA expression. This is, to our knowledge, the first meta-analysis of genetic studies on the association between POP risk and COL3A1 rs1800255 polymorphism. We found that COL3A1 rs1800255 polymorphism contributes no risk to POP of Brazilian and Asian population but.
  3. CTGF could revert the inhibition of α-SMA, fibronectin, and Col3A1 expression and the increase in E-cadherin expression mediated by miR-133b overexpression. Furthermore, the group overexpressing miR-133b and CTGF showed significantly higher CTGF and α-SMA levels and significantly lower E-cadherin levels than the control group
  4. COL3A1 and MCL1 were identified to be target genes of the miR-29 family, and transfection with miR-29abc mimics in MG-63/MTX and U2OS/MTX cells decreased COL3A1 and MCL1 mRNA and protein expression
  5. The expression curve of both groups was u-shaped and approximated a ratio of 1 (i.e., comparable to baseline COL3A1 expression), with a significant higher expression ratio of MSCs seeded onto NeuraGen® Nerve Guides after 21 days (1.696 ± 0.132 vs. 0.664 ± 0.192, P < 0.001; ). FBLN
  6. As expected, ACHN cells are low or negative for COL3A1 expression. Immunoprecipitation of COL3A1 protein from RD cell extracts. Lane 1 is 10% input, lane 2 is Rabbit (DA1E) mAb IgG XP ® Isotype Control #3900, and lane 3 is COL3A1 Antibody
  7. Taken the results of expression analysis and survival analysis into consideration, 8 up-regulated hub genes (FN1, COL3A1, FBN1, BGN, COL5A2, THBS2, COL5A1 and SPARC) were discovered not only significantly up-regulated in gastric cancer groups but also predicted poor prognosis in patients with gastric cancer (Figure 4A and Figure 4C-J)

CAT#: MP202801. The primer mix has been tested to generate satisfactory qPCR data on ABI 7900HT by using the following PCR program: Stage 1: Activation: 50 °C for 2 min; Stage 2: pre-soak:95 °C for 10 min; Stage 3: Denaturation: 95 °C for 15 sec, Annealing: 60°C for 1 min; Stage 4: Melting curve: 95°C for 15 sec, 60°C for 15 sec, 95°C. Importantly, COL3A1 expression was inversely correlated with let-7d levels in RCC clinical specimens. Our findings suggest the involvement of the let-7d-COL3A1 regulatory pathway in RCC growth and metastasis. Macrophages, which are abundant in the tumor microenvironment,.

For more info on COL3A1, check out the COL3A1 Infographic We have 30,000+ of these available, one for each gene! check them out. In this infographic you will see the following information for COL3A1: database IDs, super-family, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post translational modifications, and related. According to the expression profile of uterine cervix, COL3A1 is highly expressed in uterine cervix. So, it is likely that anti-Collagen III/COL3A1 antibody (monoclonal, 9H9) M00788 will work for IHC-P with uterine cervix

[Inhibition of COL1A1 and COL3A1 expression by RNA

  1. (A) Comparison of CTCF, COL1A1, and COL3A1 mRNA expression between BGC823 and HCG27 by RT-qPCR. (B) Real-time qRT-PCR was performed to detect the expression of the indicted genes to verify the effectiveness of knockdown. (C) BGC823 cells were treated with siRNA for 24, 48, and 72 h, and the MTT index was measured based on the MTT assay. The.
  2. The roles of the distinct FACITs family members with COL12A1 in CRC. A, COL12A1, COL3A1, COL5A1, COL5A2, and COL6A3 were found to be significantly correlated with COL12A1. Spearman was used as statistical method. B-F, mRNA expression of FACITs family members was found to be overexpressed in CRC tissues compared with the normal tissues
  3. Conversely, COL1A1, COL3A1, α‑SMA, and SMAD3 mRNA and protein expression appeared to be downregulated in rat HSCs transfected with miR‑203 mimics. Notably, the inhibition of miR‑203 expression was revealed to promote HSC proliferation, whereas increased miR‑203 expression suppressed the proliferative capabilities of HSC‑T6 cells
  4. From literature placenta does express COL3A1. From Uniprot.org, COL3A1 is expressed in uterine cervix, skin fibroblast, liver, placenta, colon carcinoma, among other tissues. Regarding which tissues have COL3A1 expression, here are a few articles citing expression in various tissues: Colon carcinoma, Pubmed ID: 786488
  5. For 6 genes (TP53, COL3A1, COL4A1, MMP1, MMP9, TIMP4), different gene expression profiles were observed only in the cells from the UVB irradiation model, indicating major influence of the environment on these biomarkers
  6. Similar to mRNA expression, chromatin immunoprecipitation also showed an increase in the level of histone H3 acetylation of the Fbn1 gene, but not of the Col3A1 gene. Our present findings suggests that the change in expression of the Fbn1 gene is epigenetically regulated, but the expression of the Col3A1 gene may either be independent of.
  7. According to the expression profile of uterine cervix, COL3A1 is highly expressed in uterine cervix. So, it is likely that anti-Collagen III/COL3A1 antibody A00788-3 will work for IHC with uterine cervix

circCOL3A1-859267 Regulates Type I Collagen Expression by

  1. e the mRNA expression levels of COL1A2 (a), COL3A1 (b), FN1-EDA (c), and CTGF (d)
  2. (e) Relative protein expression of COL1A2, COL3A1 and phospho-Smad3 in fibroblasts treated for 24 h with vehicle (saline) or 12 μg/mL cANGPTL4 in the presence or absence of 10 ng/mL TGFβ. Bars.
  3. Census tier 2. This is a putative cancer gene, from Tier 2 of the Cancer Gene Census . Tier 2 genes have strong indictations of a role in cancer. This is NOT an expert curated gene . Mouse insertional mutagenesis experiments DO NOT support the designation of COL3A1 as a cancer causing gene. This gene does not have a cancer hallmark
  4. is muscle gene.

COL3A1 (Myc-DDK-tagged)-Human collagen, type III, alpha 1 (COL3A1) Expression varies depending on the nature of the gene. Product Components: The ORF clone is ion-exchange column purified, transfection-ready dried plasmid DNA, and shipped with 2 vector sequencing primers COL3A1 expression was associated with ECM receptor interaction, regulation of actin cytoskeleton and focal adhesion pathways via GSEA analysis. In conclusion, COL3A1 may be a molecular biomarker for prognosis and immune infiltration in pan-cancer. It might act as a potential target for a new insight of human cancers management COL3A1 HEK293T cell transient overexpression lysate (as WB positive control COL3A1 expression changes between the normal tissues and different cancer tissues of CRC by TCGA dataset. The n indicates the total cases of different categories. The p values are shown above the transverse lines, which are calculated using two-tailed and unpaired Student's t test Expression System: E.coli: Purity > 90% pure: Molecular Weight: Form & Buffer: Supplied in liquid form in 6M guanidine hydrochloride and 20mM Tris buffer See all options for COL3A1 protein. Storage & Safety. Storage: Store at 4 deg C in a working aliquot for 1 week. For long term storage, aliquot and freeze at -20 to -80 deg C, avoid repeat.

Developmental Changes of Col3a1 mRNA Expression in Muscle

COL3A1 Transcriptome. HumanBase was utilized to generate glomerular and tubular COL3A1 transcriptomes i.e., the network of genes/proteins modulated by a change in the COL3A1 expression level from baseline/healthy kidneys. The glomerular (A) COL3A1 transcriptome (average strength of 0.8 ± 0.08, degree o The relative of COL3A1 expression levels on mRNA: (a) pPZ-2 (COL3A1-2); (b) pPZ-3 (COL3A1-3); (c) pGAP-4 (COL3A1-4); (d) pGAP-5 (COL3A1-5). In conclusion, to obtain hydroxylated rhCOL3A1, pGAPZ α B-P4H should be chosen as the fermentation strain on account of high and stable expression of recombinant P4H gene at mRNA level, and has a. MiR-29b, COL1A1, COL2A1, COL3A1 and SOX9 gene expression of BMSC cocultured with OA cartilage and OA bone explants. (a) miR-29b (white bars), COL1A1 (light grey bars), COL3A1 (dark grey bars) and.

Collagen, type III, alpha 1 - Wikipedi

  1. Furthermore, COL3A1 and COMP expression levels were correlated with the TNM stage in PTC patients. These four DEGs might be promising biomarkers for early-stage PTC, and provide an experimental.
  2. a cribrosa and in the TM [102, 103]. A study that explored the expression of genes using expression profiles data from TM tissue, found a different expression of COL3A1 gene in patients with POAG compared to controls
  3. The expression of Col3a1 was not increased at day 3, although it was at day 5 after treatment with the TGF-β isoforms. Therefore, the following experiments were performed at 3 days (Col1a1, CTGF, α-SMA and TIMP1) or 5 days (Col3a1) after stimulation with TGF-β isoforms
  4. Based on precious studies, high expression of perlecan/HSPG2 in gliomas lead to tumor promotion through the transformation of brain extracellular matrix into tumor microenvironment (Hu et al., 2016). In addition, high expression of COL3A1 contributes to glioma cells proliferation and migration (Shin et al., 2017)
  5. The transcription factor Nk2 homeobox 5 (NKX2-5) is predicted to target COL3A1, and we observed NEDD9 expression in the nucleus of HPAECs with or without ALDO treatment and in the nucleus of HPAECs isolated from PAH patients (PAH-HPAECs) (fig. S5, C and D, and movies S1 to S3)

Gene expression in human CRC microarray dataset. Type I alpha I collagen (COL1A1), type III alpha I collagen (COL3A1), ELN, MMP9, MMP12, TIMP3, TNF gene expressions were from existing microarray datasets through Gene Expression Omnibus (GEO).The data were analyzed using Bioconductor in R as previously described [13, 14].In GSE128449 dataset, gene microarray from colorectal tissues were. The expression vector-mediated RNAi established a HSF cell line with persistent gene knockdown for over 30 days (to 25.21% and 22.12%, respectively). CONCLUSION: COL1A1 and COL3A1 gene expressions can be specifically and efficiently inhibited in HSFs by either liposome- or vector-mediated SEC transfection Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12 COL3A1 (B-10): sc-271249.Western blot analysisof COL3A1 expression in HISM (A)andCCD-1064Sk (B) wholecell lysates and human bone marrow tissue extract (C). 114K- AB C COL3A1 COL3A1 (B-10) HRP: sc-271249 HRP. Direct western blot analysis of COL3A1 expression in non-transfected 293T: sc-117752 (A), human COL3A1 transfected 293T

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Gene expression in human liver fibrosis associated with

Data mining-based study of collagen type III alpha 1

Col3a1. 245. Annotation score: Annotation score:1 out of 5. The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score cannot be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein Gene expression Figures 2 and 3 show the relative expression distribution of COL1A1, COL3A1, DEFB4B, FOXP3, IDO1, IL6, MMP9, TGFB1, TGFBR1 and TNFA transcripts of uter-ine biopsy of 25 horses grouped by age (younger and older than 10years). The expression values are normal-ized with 3 reference genes: glyceraldehyde-3-phosphat A, Expression of ACTA2 in HAFs by immunofluorescent staining (scale bar is 50 μm). B, Col1a1, Col3a1 and ACTA2 expression was detected using western blot assay in Ang-II-induced HAFs. Expression of miR-23b/27b precursor (C), miR-23b-3p and miR-27b-3p (D) was determined using RT-qPCR assay in Ang-II-induced HAFs. Data are shown as mean ± SEM. animals Communication Dietary Lecithin Decreases Skeletal Muscle COL1A1 and COL3A1 Gene Expression in Finisher Gilts Henny Akit 1,2,*, Cherie Collins 3, Fahri Fahri 1, Alex Hung 1, Daryl D'Souza 4, Brian Leury 1 and Frank Dunshea 1 1 Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria 3010, Australia; Fahri.Fahri@foodauthority.nsw.gov.au (F.F.

The expression of α‐SMA, COL1A1, COL3A1, TIMP‐1 was determined by immunohistochemistry. The RT‐qPCR, Western blotting and immunofluorescence staining were conducted to determine expression of miR‐29b‐3p, COL1A1, and COL3A1. CCK‐8 assay and flow cytometry were performed to evaluate viability and apoptosis were performed to evaluate mRNA and protein expression of miR-133b targets, E-cadherin, α-smooth muscle actin (SMA), fibronectin, and collagen 3A1 (Col3A1), in HK2 cells transfected with miR-133b under TGF-β1 stimulation. A 24-month-old unilateral ureteral obstruction (UUO) mouse model was established and injected with transfectio

The expression of Col1a1 was significantly reduced in the LM+GM group on days 7 and 15 postinjury (Fig. 3C). In contrast, the Col3a1 gene expression profile was similar between the LM and LM+GM groups, and the expression in both groups peaked on day 7 and returned to baseline on day 30 enhanced expression of COL3A1 and CCL7 genesin vitro. The mRNA levels of COL3A1 and CCL7 were inversely correlated with let-7d level in RCC clinical specimens. Conclusions:These results suggest that let-7d may suppress RCC growth, metastasis, and tumor macrophage infiltration at least partially through targeting COL3A1 and CCL7 Western blot analysis revealed that CvME significantly upregulated the expression of COL3A1 and bFGF and increased the Smad-mediated collagen production in granulation tissue. These findings suggest that C. viscosa promoted the wound repair process by attenuating the Smad-mediated collagen production in wound granulation tissue Expression of one of these proteins, C1r (complement component 1), is shown to be entrained to the vascular smooth muscle PTH1R-Mkl-1 signal relay controlling Col3a1 and Col1a1 expression. Discovery of this connection may lead to novel approaches to monitor and inhibit arterial fibrosis

Interleukin 17 and senescent cells regulate the foreign

COL3A1 gene: MedlinePlus Genetic

We found positive correlations between COL3A1 and COL5A1 expression in GC cells, and confirmed that miR-29a-3p is the common regulator of their expression. RNA immunoprecipitation assays based on Ago2, Dicer, and exportin-5 showed that SFA could promote mature miR-29a-3p generation with expression of its targets, COL3A1 and DNMT3A. Gain of function of miR-29c inhibited the expression of COL3A1 and DNMT3A at protein and mRNA levels, secreted COL3A1, and rate of cell proliferation. Loss of function of miR-29c had the opposite effect. E 2, P, and their combination inhibited miR-29c in leiomyoma smooth muscle cells (LSMC. Collagen, type III, alpha-1 (COL3A1) is essential for normal collagen I fibrillogenesis in many organs. There are differences in phenotypes of mutations in the COL3A1 gene in humans and mutations in mice. In order to investigate whether the regulation and gene network of COL3A1 is the same in healthy populations of mice and humans, we compared the quantitative trait loci (QTL) that regulate. Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12. This gene encodes the pro-alpha1 chains of type III collagen, a fibrillar.

Sox5 and Sox6 are required for notochord extracellularEhlers-Danlos Syndrome, Classic Type, 2 disease: Malacards